Development and Optimization of Polymethyl Methacrylate Nanoparticle Formulation for Veterinary Delivery of Progesterone and Ivermectin

https://doi.org/10.55977/etsjournal.v01i01.e022002

Authors

  • Osvaldo Valarini Junior Programa de Pós-Graduação em Agroquímica
  • Paulo Cardozo Carvalho de Araújo Instituto Federal Goiano
  • André Luis Gomes Simões Programa de Pós-Graduação em Engenharia Química, Universidade Estadual de Maringá (UEM)
  • Lauro Bücker Neto Departamento de Química, Universidade Estadual de Ponta Grossa (UEPG)
  • Aline Coqueiro Departamento de Química, Universidade Estadual de Ponta Grossa (UEPG)
  • Fernanda Vitória Leimann Programa de Pós-Graduação em Tecnologia, Universidade Tecnológica Federal do Paraná (UTFPR)
  • Odinei Hess Gonçalves Programa de Pós-Graduação em Tecnologia, Universidade Tecnológica Federal do Paraná (UTFPR)
  • Willyan Machado Giufrida Faculdade de Engenharia e Arquitetura (FEITEP)
  • Fabiano Guimarães Silva Instituto Federal Goiano, IF Goiano - Campus Rio Verde, Rio Verde, 75901-970, Goiás, Brasil

Keywords:

PPolymethyl Methacrylate, Ivermectin, Progesterone, Single Emulsion, Nanoparticles, Optimization

Abstract

The main objective of this study was to produce and optimize polymethyl methacrylate (PMMA) nanoparticles via a simple emulsion process followed by evaporation. The compounds used were chloroform, lecithin, progesterone, ivermectin and PMMA in the organic phase and water and polyvinyl acetate (PVA) in the aqueous phase. The NPs/P4 had a diameter of 154.3 ± 0.1 nm and the NPs/IM 184.1 ± 0.1. The optimization of this diameter occurred by a Box-Behnken response surface. The particles formed were characterized by MET, SEM, TGA/DTA and FT-Raman techniques to determine their morphology, thermal resistance and elucidate their conformational structure.

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Published

2022-04-11

How to Cite

Valarini Junior, O. ., Cardozo Carvalho de Araújo, P., Gomes Simões, A. L., Bücker Neto, L. ., Coqueiro , A. ., Vitória Leimann , F. ., Hess Gonçalves , O., Machado Giufrida, W. ., & Guimarães Silva, F. . (2022). Development and Optimization of Polymethyl Methacrylate Nanoparticle Formulation for Veterinary Delivery of Progesterone and Ivermectin. Engineering & Technology Scientific Journal, 1(1), e022002. https://doi.org/10.55977/etsjournal.v01i01.e022002

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Vol. 1 No. 1 (2022)

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Research Article
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Copyright (c) 2022 Osvaldo Valarini Junior, Paulo Cardozo Carvalho de Araújo, André Luis Gomes Simões, Lauro Bücker Neto, Aline Coqueiro , Fernanda Vitória Leimann , Odinei Hess Gonçalves , Willyan Machado Giufrida

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