Desenvolvimento e Otimização da Formulação de Nanopartículas de Polimetil Metacrilato Para Entrega Veterinária de Progesterona e Ivermectina
Palavras-chave:
Polimetil Metacrilato, Ivermectina, Progesterona, Emulsão Simples, Nanopartículas, OtimizaçãoResumo
O objetivo principal deste estudo foi produzir e otimizar nanopartículas de polimetil metacrilato (PMMA) via processo emulsão simples seguida de evaporação. Os compostos utilizados foram clorofórmio, lecitina, progesterona, ivermectina e PMMA na fase orgânica e água e poliacetato de vinila (PVA) na fase aquosa. As NPs/P4 tiveram um diâmetro de 154,3 ± 0,1 nm e as NPs/IM 184,1 ± 0,1. A otimização desse diâmetro ocorreu por uma superfície de resposta de Box-Behnken. As partículas formadas foram caracterizadas pelas técnicas de MET, MEV, TGA/DTA e FT-Raman para a determinação da morfologia, resistência térmica e elucidar sua estrutura conformacional.
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